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KMID : 0923620220220050039
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Immune Network
2022 Volume.22 No. 5 p.39 ~ p.39
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RNA Metabolism in T Lymphocytes
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Choi Jin-Ouk
Ham Jeong-Hyeon
Hwang Soo-Seok
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Abstract
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RNA metabolism plays a central role in regulating of T cell-mediated immunity. RNA processing, modifications, and regulations of RNA decay influence the tight and rapid regulation of gene expression during T cell phase transition. Thymic selection, quiescence maintenance, activation, differentiation, and effector functions of T cells are dependent on selective RNA modulations. Recent technical improvements have unveiled the complex crosstalk between RNAs and T cells. Moreover, resting T cells contain large amounts of untranslated mRNAs, implying that the regulation of RNA metabolism might be a key step in controlling gene expression. Considering the immunological significance of T cells for disease treatment, an understanding of RNA metabolism in T cells could provide new directions in harnessing T cells for therapeutic implications.
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KEYWORD
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T-lymphocytes, RNA, RNA metabolism, Immunity, Cellular
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